Lack of Vitamin D declines the level of estrogen

Vitamin D is important for a good health conditions and can be gained from food such as cereals, milk and by exposing to sunlight. Lack of vitamin D in men is amplified by lowering the levels of estrogen, but not by testosterone.

According to a previous study made deficiency of vitamin D and the low levels of estrogen are at independent threat of hardened and narrow arteries and damaged bones. A national study was carried out by the researchers, for examining the relation involving Vitamin D, bone health, and heart. It is also said that the, vitamin D supplements which can be prescribed to cure osteoporosis, can be useful to avoid heart disease.

Vitamin D, testosterone and estrogen are steroid hormones, formed from cholesterol. The level of cholesterol in blood controls bone health and arterial. Research gives a much improved understanding as to how Vitamin D, estrogen and testosterone work to affect bone health and cardiovascular health.

After using the same measure of estrogen levels, vitamin D deficiency in men were also at high risk of cardiovascular syndrome. This results support the point as to how important it is to have a appropriate quantity of vitamin D are to good for bone health and risk of rising osteoporosis and heart disease is very high on the combined interaction of how any such vitamin shortage interacts with both the sex hormones.

Natrecor a heart failure drug is found to be ineffective

A latest study published by New England Journal of Medicine says, Natrecor (nesiritide),the heart failure medicine is not effectual and is associated to increasing rates of possibly hazardous low blood pressure.

The heart failure drug Natrecor was approved in 2001 to help patients breathe without difficulty. According to the research, since the medicine had no major consequence on breathing problems or any other disease difficulty may also cause low blood pressure.

The study authors have noted that the research has recognized the possible risk and benefits of the drug in people with heart failure who have serious difficulty in breathing a condition also known as dyspnea as the illness is worsening.

To come up with new drugs, we require adequate plan and must have enough data, to rework the whole process so that the doctors and patients are comfortable. Billions of dollars were spent on Natrecor (nesiritide), where as we could have used Lasix which costs penny for single dose. We need to rethink the entire pharmaceutical industry process.

Even though, there were small non-specific effect on reducing death, re-hospitalization and improve dyspnea with nesiritide use for severely worsening heart failure. This result improves clinicians about the possible danger and benefits of Natrecor (nesiritide) in treating such patients.

In 2001 Food and Drug Administration (FDA), U.S. approved nesiritide, the anxiety were raise which may also be associated with worsening of renal functioning and mortality.

It is said that Nesiritide, shall be not be taken away from the market, as it doesn't harm anyone, just because it doesn't hurt people it doesn't means that it should be made available in the market.

Teva Loses Battle to Pfizer, Succeed Patent Challenge

Teva Pharmaceutical Industries gave a tough fight to protect the patent of the best- sold drug in the market. Teva Pharmaceutical Industries has lost the challenge, as they are not permitted to market the generic version of the Viagra.

As Pfizer Pharma has won the legal battle, and can retain the patent rights of the most blockbuster drug, that cures male impotent, called as Viagra. The major drug used for the preparation of Viagra is Slidenafil Citrate. Teva Pharmaceutical Industries will not be allowed to market the generic version of this medicine till October, 2019, by order.

As Pfizer Pharma, continues to carry on with the exclusive right into producing and marketing Viagra. The management of Pfizer Pharma is extremely content about the fact that the court has understood the necessity and the effectiveness of this drug which is used to treat erectile dysfunction (ED) or male impotent. Pfizer Pharma, also says that court has not only protected their intellectual property rights; but has also protected their patent rights from getting violated in the market.

Teva Pharmaceutical Industries builds a victorious generics industry, standing to test the patents exclusively for the owned drugs. Teva is now finding itself to the other side where they have secured its own owned products. Teva Pharmaceutical Industries has declared that even they are satisfied with the court’s result and are waiting to begin an experiment on September 7, 2011’.

Legal Action Over FDA by US Cigarette Companies

Lorillard Tobacco, Santa Fe Natural Tobacco, Commonwealth Brands, Liggett Group and, RJ
Reynolds Tobacco are the five companies that are involved in common lawsuit filed against, US
Food and Drug Administration (FDA).

All these listed major cigarette companies say that, the lawsuit has been filed against Food and Drug Administration (FDA), because the new graphic warning labels will be essential on the cigarette packets only from September 2012 onwards. The suit was filed to holdup the challenges to reinforce the upcoming new law.

In the list of complaint approximately adds 41 pages, which include saying, the newly designed
label would unlawfully force the cigarette manufactures to make their customers miserable, discouraged and terrified before purchasing their product. They are also asking Food and Drug Administration (FDA) to come-up with simple and effective uncontroversial warnings label rather then to make the cigarette pack a public notice for anti-smoking campaign by government.

All the major cigarette companies are arguing over the new law, because it is violating the constitutional right of every citizen of free speech. In the new law government wants the Cigarette companies to endorse their anti-smoking note on the pack. All the major tobacco companies have joint their hands to fight against this graphic label warning, as it is violating their freedom of speech.

Sexual Dysfunction in Men Linked to Partner's Friendship with Males

Sexual dysfunction is rampant these days when our lifestyle and way of living has become very irregular. This dysfunction is often the result of a condition called as erectile dysfunction. There are several studies that have been conducted recently and according to one of those, there have been found a revealing fact about male impotency. It is observed that erectile dysfunction is more prominently found in males in situations when there female partners share strong relationships with their male friends.

Benjamin Cornwell, professor of sociology at Cornell University and Edward Laumann, professor of sociology at the University of Chicago has come up with a new conclusion. They say that there is a condition known as “partner betweenness” wherein a man’s female partner share a stronger rapport than he himself with his male friends. This causes the female romantic partner to come in between the man and his friends.

According to these expert scientists from renowned Universities, the syndrome of ‘partner betweenness’ can dampen a man’s feelings of autonomy and privacy, which are central to traditional concepts of virility.

For conducting this study, data was taken from over 3,000 Americans whose age range from 57 to 85 years. Amongst them, around one fourth of the men were seen to have experienced ‘partner betweenness’. This problem occurs mostly in men whose ages range between 57 and 64, a transition time when partners genuinely feel the need of each other. This is the time when sex plays a very important role as partners lose the usual grip over their youth zest.

Edward Laumann quoted in Chicago Sun-Times “This is when people are retiring, leaving the work force, reorganizing their life. This is very threatening to a male’s understanding of himself,” he also observes that it is not the mere taking of pills that leads to such adverse effects on the erectile dysfunction. The reason is deep within. Social and psychological reasons lead to such conditions in men. Erectile dysfunction medicines such as Viagra or Kamagra

He additionally said that this excessive attachment with the husband’s friends and repetitive alignment with their thoughts and ideals dampen the spirits of their husbands and leads to identity loss and lack of self confidence. This in turn leads to the inability to perform sexually as his mind is already doomed into diffidence.

Try This Unusual Method to Reduce Depression

It is time in your life, if you believe your sorrow and pain, perhaps the death of loved ones, or falling apart,and relationship.I know how it feels to be depressed. Pregnancy in the chest and weakness of life, numbness, feeling cut off and the feeling of hopelessness.
Many people start taking antidepressants when they feel being depressed. Let me tell you antidepressants help you for short period of time. There are many ways that can recede depression level. Depression badly affects various life-style aspects of life such as it leads to erectile dysfunction, hair loss.
Despair: I know it varies from person to person, as well symptoms. Depression is more than the Blues. It can be a killer, especially among young people. Many do not suffer not want to risk the side effects that some prescription drugs do. Here are some ideas to deal with depression natural and healthy manner.
Spend Time: To spend time quietly and gently ask the feelings and thoughts of what they want. Wait and see if the answer comes. I do not think some of you are depressed you need to pay attention to it. This allows you to start with heal.Get something you know you are good at. When it reaches the target Improve your self-esteem. This naturally raises You can spirits.
Meditate: Meditation helps the mind to release tension. Meditation tape can guide, how to act. Relaxation and rest is the key to making a noise mind. Keep Journal and write down the emotions, it helps you keep track of your depressive episodes. This in turn can lead you all to raise nutritional or emotional, and you can manage before they start. Eat enough fruits and vegetables, and make sure that the iron and thyroid levels are where they should be.
Nutrition: has an important role in energy level and body functioning. If something is not right in our body, it can occur mood. To pay special attention to food intake.Exercise, especially aerobic raise the level of serotonin in the brain. Serotonin is useful to add mood. Many prescription drugs on the market will increase serotonin levels medication, while the use of this course.

First FDA approved Anti-venom Medicine

After a relatively small trial FDA has approved anti venom medicine known as Anascorp. Anascrop (an intravenous therapy) is indicated to treat venom of Arizona bark scorpion. The medicine which was available before this approval was not approved by FDA as the treatment was producing severe side effects such as Anaphylaxis (acute multi-system).

Bark scorpion is most venomous one. Its sting can cause paralysys in stung part, severe pain, mouth frothing and vision problem.

Earlier, researchers could not get FDA approval for Anascorp because of lack of clinical trials. There were some obstacles to have participants as exposing people to highly venomous sting was potential risk. But Dr Leslie Boyer knew how important anti-venom was and she searched for hospitals that were ready carry out clinical trial on patients stung by Bark Scorpio. Dr Leslie decided to carry out an open trial.

Initially Dr Leslie found only two hospitals ready to participate. In a year, fifteen kids were successfully treated with Anascorp. Wondering effects were seen with even a small dose of Anascorp. Symptoms of Bark scorpion sting were treated in eight children within 3-4 hours. Patients without Anascrop had to stay longer in ICU before they were declared out of danger.

The trial was started in 2008 and lasted till 2010. 200 children were treated with the anti-venom drug. Trial is longest believed to be the longest running anti-venom trial. An approval based on such unusual trial is also a remarkable one in the history of FDA.

Greater Muscle Mass Lowers Risk of Diabetes Type 2

Link between muscle mass and insulin resistance has been confirmed in a study at University of California. It is found that low muscle mass may lead to poor insulin resistance and can eventually result in diabetes type 2. Pre-diabetics are always recommended to lose weight in order to cure diabetes.

New research sheds light on importance of muscle building. This has eliminated major cause of worry for overweight pre-diabetes patients when they are asked to lose weight. People with higher than normal sugar level but, below diabetic sugar level are known as pre-diabetics.

Research included 13,644 participants. People with greater muscle mass (with respective to their body size) were found resistant to insulin and at lower possibility to develop diabetes. Clear conclusion was that greater muscle help keep diabetes type 2 away.

Findings clarifies that weight loss is not the only remedy to prevent diabetes. Being fit is equally important and good fitness helps to develop more insulin resistance. Dr. Preethi Srikanthan, a lead researcher, of a survey named as U.S. National Health and Nutrition Examination Survey III.

Until now, BMI (Body mass index = ratio of height and weight) was being determined to calculate risk of type 2 diabetes. Dr srikanthan and team studied SMI (Skeletal Mass Index) against risk factors of diabetes type 2. They found that SMI is inversely proportional to diabetes risk factors. Means, diabetes factors were low in people with higher SMI. 10% increment in SMI decreased insulin resistance and pre-diabetes condition by 11% and 12% respectively

New Blood Test For Early Diagnosis of Alzheimer

A research done at Australian national research organization CSIRO, says that early diagnosing of disease Alzheimer is possible with a blood test

273 Alzheimer patients participated in research. These all patients were earlier diagnosed by means of brain scan and cognitive tests. 85% of the diagnosis result of blood test were correct. Needless to say the study has delighted physicians and scientists across the world. Result data of the blood test was compared to other research studies done by other group. It was found that accuracy of result is matching with every available diagnosis methods.

Research study was presented at 88th Alzheimer’s Association International Conference by Samantha Burnham and her team members.

The proposed blood test includes measuring level of specific proteins and hormones in blood. A protein known as beta-amyloid is widely believed to be causing Alzheimer. Along with beta-amyloid protein eight other proteins level was measured. Five of these eight proteins have been already confirmed by other stdies. Name of the rest of three proteins have not been disclosed as research team awaits more sophesticated result data.

Lipid Lowering Drugs

Lipid lowering drugs

What is lipid?
Lipid is white wax like organic substance made up of sterols, fats, vitamins soluble in fat, diglycerides, monoglycerides and phospholipids. There are eight types of lipids found in human body. Lipids perform many important functions such as membrane formation, storage of energy, carrying signals and dissolve vitamins that are not soluble in water. Triacylglycerols, cholesterol and phospholipids are most common types of lipids found in food.

• Fatty acyls
• Glycerolipids (triglycerides)
• Glycerophospholipids
• Sphingolipids
• Sterol lipids
• Prenol lipids
• Saccharolipids
• Polyketides

Cholesterol

Cholesterol is sterol lipid. It is an essential lipid for human body. Cholesterol maintains permeability of cell membrane i.e. maintains easy flow of molecules to pass through membrane. Body system requires cholesterol to produce steroidal hormones and bile acid. Excess presence of cholesterol is very harmful despite its important functions and necessity. High cholesterol level leads to heart problem such as blockages in coronary arteries and veins. LDL (Low density liporprtien) is strongly associated to critical health conditions while, on the other hand, HDL (high density lipoprotien) is considered to be good cholesterol.
* Statins: Statin drugs are most prescribed drugs class to lower sterol lipid (cholesterol) level in bloodstream. Statin drugs work by preventing HMG-CoA reductase enzyme from getting activated. HMG-CoA reductase decides the rate at which cholesterol is synthesized. Inhibition of these enzymes reduce the cholesterol formation and increase protein (Low-Density Lipoprotein Receptor) that helps cells to absorb cholesterol-rich LDL.
Statin drugs lowers LDL by 18% to 55% in blood.
Drugs of This Class are....

• Lipitor, Torvast (Atorvastatin)
• Lipobay, Baycol (Cerivastatin)
• Lescol, Lescol XL (Fluvastatin)
• Mevacor, Altocor (Lovastatin)
• Mevastatin
• Livalo, Pitava (Pitavastatin)
• Pravachol (Pravastatin)
• Crestor (Rosuvastatin)
• Zocor (Simvastatin)
• Vytorin (Simvastatin+Ezetimibe)
• Advicor (Lovastatin+Niacin)
• Caduet (Atorvastatin+Amlodipine Besylate)
• Simcor (Simvastatin+Niacin)

* fibrates are used to treat condition known as hypertriglyceridemia, a condition where blood contains high level of triglycerides. Triglycerides is another type of lipid responsible for hardening of arteries. Fibrate works through sticking to receptors of PPAR-α. Activation releases an enzyme that reduces amount of triglycerides and LDL. Fibrate also increases level of the good cholesterol(HDL). Double action of fibrates results in low LDL and high HDL. Fibrates are indicated for prevention of coronary heart disease. Fibrate may cause muscle damage.
Fibrates typically lower triglycerides by 20% to 50%.
Drugs of this class are....
* Bezalip (Bezafibrate)
* Modalim (Ciprofibrate)
* Clofibrate
* Lopid (Gemfibrozil)
* TriCor (Fenofibrate)
Other lipid lowering drug classes are....
* niacin: Lowers LDL by 5-25% and increase HDL by 15-35%. Side effects include liver damage and hyperglycemia.
* bile acid sequestrants
* phytosterols
* Orlistat (Xenical): Xenical works by preventing absorption of fat from food. This drug inhibits an enzyme that is responsible for synthesis of triglycerides. Xenical is also being indicated to treat obesity since its action reduces calories produced from food.

An Introduction to Diabetes Medications

Brief about Diabetes
Human body requires energy to perform daily activities. Energy is also required for internal organs of body for good functionality. Every cell of the body does respiration process to produce energy from the eaten food. A hormone, known as insulin (secreted by pancreas gland), help body cells to use glucose and generate energy out of it. Diabetes is a disease in which body system fails to produce enough insulin. Because of inability of body cells to transform glucose in energy, accumulation of glucose occurs which eventually leads to many diabetes complications.
Types of diabetes: Diabetes Type 1, Diabetes Type 2.

Diabetes Drugs

For type 1 diabetes insulin, pramlintide and exenatide are to be administered by injection or inhalation. Range of oral medicines, belong to different drug-class, are available to treat type 2 diabetes.

Types of Drug For Diabetes

Sulfonylureas

Sulfonylureas is class of drug belong to anti-diabetic drugs they are indicated for both type 1 and 2 diabetes. Sulfonylureas increase insulin release by working on beta cells of pnacrease gland.
Sulfonylureas drugs increase electrical positivity on membrane of beta cells of pancreas gland by preventing polarising of potassium tonic. Increased positivity leads to release more Ca (calcium) which helps stored insulin to release in body.
Drugs that are called sulfonylureas are......

• Acetohexamide
• Tolbutamide
• Chlorpropamide
• Tolazamide

Second generation

• Glipizide

Third generation

• Glimepiride

Working mechanism (Pharmacokinetics) and effect on body (Pharmacodynamics) of these drugs are different, though, their resulting action is same i.e. release of more insulin. With sole purpose of releasing more insulin in body different drugs are formulated with different techniques hence side effects of all drugs are different too.

Meglitinides

Meglitinides are indicated for diabetes type 2. Meglitinides works in same manner as that of sulfonylureas. Like sulfonylureas, meglitinidesin too bind its self but at different place.
Drugs of this class are....
Nepaglinide (Prandin)
Nateglinide (Starlix)
Meglitinide may cause low level of glucose (Hypoglecemia) because of high insulin released. Take it before half an hour of meal.

Biguanides

Biguanides are more effective than sulfonylureas and meglitinide. In stead of increasing insulin level biguanides lowers the process known as Gluconeogenesis that forms glucose. It also helps tissues to absorb glucose.
Metformin belong to this class of diabetes drugs. Metformin is one of the most popular drug being used in combination with other drug for diabetes type 2.

Thiazolidinediones

Thiazolidinediones are also know as glitazones. They acts in two ways to reduce glucose level, reduces natural process of glucose formation; helping cells to utilize glucose. Being greater effective, these drugs shows less side effects.

• Avandia (Rosiglitazone)
• Rezulin (Troglitazone)
• Actos (Pioglitazone)

Thiazodinediones works by sticking itself to receptors called PPARs.

Some Quick Facts on Cancer & Its Type

Mouth cancer, breast cancer, blood cancer (Chronic leukaemia) are some of the types of cancers we have heard of. The fact is, there are more than 100 types of cancers. Cancer can develop to any part of the body. No body part is above cancer. HIV positive patients may catch skin cancer known as kaposi's sarcoma, liquid secretion cancer, cervical cancer. Six different types of cancers can occur in eyes. There are two types of breast cancer.

Types of Cancers

Thyroid Cancer

There are four types of thyroid cancer. 1) papillary 2) medullary 3) anaplasticand 4) follicular. High cholesterol, 40+ age, first six months after pregnancy, severe depression, continuous contact with litium can cause thyroid cancer.

Appendix Cancer

Appendix Cancer (Appendiceal Carcinoma) found in rare cases. In most cases \n appendix cancer spreads out of the appendix. Surgry is very difficult and its \n treatment is rare too. 10 cms long appendix is believed to be almost useless organs in body. Five types of cancers can develop in appendix.
Malignant Carcinoid, Mucinous Adenocarcinoma, Adenocarcinoma, Adenocarcinoid, \n and Signet Ring Adenocarcinoma. Surgery is the only well known remedy for appendix \n cancer.

Breast Cancer

Breast cancer is fastest growing cancer in the world. Can be found in both \n male and female, yet rare in male. Surgery, chemo therapy, radiation therapy and \n vaccine therapy have been used so far to treat this cancer. Female death toll caused by breast cancer is the second largest in the world.
Not necessarily develop in breast only but can also develop outside of breast. Breast cancer can infect lungs which may result into lung cancer.

Lung Cancer

Unwanted formation of lung cells or tissues causes lung cancer. Tobacco intake for long period of time, constant company of smoker, interaction with radon gas (very rare case) and pollution also leads to develop lung cancer. Genetic factors plays important role for those who have taken tobacco for short period of time.
Two basic types of lung cancers are seen: 1) Small cell cancer also called \n oat cell cancer 2) Non-small cell cancer (most common lung cancer, with 70%).
Non-small cell cancer has been divided into five category depending upon appearance of cells

• Squamous cell carcinoma
• Large cell carcinoma
• Adenosquamous carcinoma
• Adenocarcinoma
• Undifferentiated carcinoma

According to World Health Organization estimates 1.4 millions (and growing) death each year by lung cancer.

Prostate Cancer

Prostate cancer is believed to 'totally male' cancer. Prostate cancer surviving person feels pain during urination or sexual intercourse. This cancer poses danger to the born of new baby.
Vitamin E and celenium deficiency or excess of vitamin D may invite prostate cancer. Nickol masa was the first to identified this cancer in 1536. Other family members must be wary if any of the members found this cancer.

Kidney Cancer

Kidney cancer starts within any of the artery or vein in kidney. Mostly found \n in small children. Kidney cancer develop before age of five.

Fact File about Cancer

58 millions people were reported died in 2007, out of which 13% i.e 7.6 millions deaths were because of cancer.
Lung cancer, Intestine cancer and liver cancer are the top three cancer causing death in male.
Breast cancer, lung cancer and intestine cancer are most deadly for fmale.
Cancer is treatable if diagnosed early.
Tobacco is number one reason to cause cancer.