A small clinical trial, conducted by Dr Paolo Barone, suggests that dopamine agonist helps to treat depression of Parkinson's patients. Dopamine agonist, such as Pramipexole, may specifically treat depression of patients of parkinson's disease. Conclusion was published on TheLancet Neurology May 10 edition.
Experts believe that depression in parkinson's disease is caused by malfunction path where domaine is being transmitted from one point to another. Although depression symptoms are found in nearly 35% of patients suffering from parkinson's disease, few studies and researches have been made on depression medication to treat it. Dopamine agonist is already being used to treat severe depression. It is learnt from the trial that Pramipexole shows direct antidepressant effects in Parkinson's disease.
Pramipexole is drug of class dopamine agonist used to treat parkinson's disease. Pramipexole is also being used to treat sexual problem caused by usage of antidepressants. Pramipexole has shown strong effects in bipolar disorder.
Effect of Pramipexole found to be double-in-action, that is, it independently treats both Motor Disability and depression. The found result of the study, positive effects of single drug on two major diseases, is considered to be very important for further studies.
Pramipexole Works?
Parkinson's is a neurodegenerative disease which affects the part of the brain (substantia nigra) responsible for body movements. The substantia nigra, located around basal ganglia, contains high level nerve cells that release neurotransmitters called dopamine. Dopamine activates its receptors in basal ganglia (a part of brain). In parkinson's disease part of brain that contains dopamine neurones does not produce enough neurones. This causes lack of dopamine signals which results in lost control of brain on movements. Pramipexole works by stimulating the malfunctioning dopamine receptors in the striatum, thereby restoring the dopamine signals needed for proper functioning of the basal ganglia.
Experts believe that depression in parkinson's disease is caused by malfunction path where domaine is being transmitted from one point to another. Although depression symptoms are found in nearly 35% of patients suffering from parkinson's disease, few studies and researches have been made on depression medication to treat it. Dopamine agonist is already being used to treat severe depression. It is learnt from the trial that Pramipexole shows direct antidepressant effects in Parkinson's disease.
Pramipexole is drug of class dopamine agonist used to treat parkinson's disease. Pramipexole is also being used to treat sexual problem caused by usage of antidepressants. Pramipexole has shown strong effects in bipolar disorder.
Effect of Pramipexole found to be double-in-action, that is, it independently treats both Motor Disability and depression. The found result of the study, positive effects of single drug on two major diseases, is considered to be very important for further studies.
Pramipexole Works?
Parkinson's is a neurodegenerative disease which affects the part of the brain (substantia nigra) responsible for body movements. The substantia nigra, located around basal ganglia, contains high level nerve cells that release neurotransmitters called dopamine. Dopamine activates its receptors in basal ganglia (a part of brain). In parkinson's disease part of brain that contains dopamine neurones does not produce enough neurones. This causes lack of dopamine signals which results in lost control of brain on movements. Pramipexole works by stimulating the malfunctioning dopamine receptors in the striatum, thereby restoring the dopamine signals needed for proper functioning of the basal ganglia.
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