Monday, May 3, 2010

Provenge Sipuleucel-T Information Side Effects

Last week Provenge finally got approval as vaccine for final stage of refractory prostate cancer. Provenge is launched by Dendreon for autologous cellular immunotherapy treatment of prostate cancer in certain men.

What is Provenge (sipuleucel-T)

Sipuleucel-T is generic for Provenge. It is not kind of any tablets. Provenge is vaccine used along with patient's immune cells collected and infused, with the help of leukapheresis process, in body system.

Prostate cancer
Prostate cancer occurs when a tumor (a tumor is rapid and abnormal growth of tissues) in prostate gland invades and destroys near by tissues and spreads to other tissues. Prostate gland, when most of the tissues are infected, fails to work normally.

Prostate cancer is associated with growth of male hormone called testosterones. DHT (Dihydrotestosterone) is needed for cancer cells to grow. DHT are converted from testosterone. Hormone (also known as analogs) therapy is used to block production of testosterone. Medicines of class antiandrogens are used to block conversion of testosterones into dihydrotestosterones. Thus, overall effects result in prevention of growth of cancer cells.

Provenge is indicated to treat refractory prostate cancer. Prostate cancer is refractory when body does not respond to hormone therapy. Provenge is an autologous cellular immunotherapy, is made up of patient's own immune cells to stimulate immune system.

Patient's cells are collected at the authorized center before 3 days of beginning of therapy.

Side Effects of Provenge

Common Provenge Side Effects

Provenge side effects includes chills, fatigue, fever, weakness, shortness of breath, wheezing, low oxygen level, dizziness, high blood pressure, headache, muscle pain, vomiting and nausea.

Serious Provenge Side Effects

Seek emergency help if any of the following side effects occur......

  • Breathing problems

  • Chest pains

  • Racing heart or irregular heartbeats
Symptoms such as nausea, dizziness, or vomiting are may related to heart or lung problems.

Provenge Dose

Therapy requires three dosages of Provenge.

Precaution to take while Provenge Therapy

Let your doctor know your medical history such as heart or lung problems or history of stroke.
Brief your doctor about all the prescription drugs, OTC drugs, vitamins, and dietary supplements name you are taking. You doctor may suggest to stop particular medications.
Infection may occur at the site of infusion or the place where cells were collected from. Seek help from your doctor you notice redness at operated site; get a fever over 100°F.

No comments:

Post a Comment