Monday, May 7, 2012

Blood Pressure Drugs Reduce PTSD Symptoms

Some blood pressure medicines have been found helpful in treating stress post trauma, says a research study.

PTSD or post-traumatic stress disorder symptoms were reduced when patients took medicines such as cozaar or diovan. Drugs of class Angiotensin 2 Receptor Blockers prevent action of receptors of angiotensin 2 enzyme.

The research outcome is significant one because it paves the way for new path to proceed on to develop treatment for PTSD. This is the first study that has linked blood pressure drug to psychological disorder such as PTSD. Dr Kerry Ressler is the author of the study. Dr Ressler is professor at Emory University School of Medicine in Atlanta, psychiatry department.

Experts caution the result did not demonstrate cause of the effect, rather just establishes link. Also, a clinical trial would require to compare efficacy against placebo. The study has been published on reputed journal, Journal of Clinical Psychiatry.

check the study details here http://www.psychiatrist.com/ppp/login/login_check_1.asp?dest=/privatepdf/2006/v67n08/v67n0810.pdf

5,000 patients participated in study. All the patients had had severe PTSD symptoms because of traumatic incident such as sexual abuse, physical abuse or experiencing violent incidents, when the study was conducted.

500 out 5000 people were subject to one incident that left them traumatized. 180 people met conditions to be diagnosed with PTSD. 26 patients were already taking blood pressure drugs of either class ARB or ACE inhibitors.

Symptoms of PTSD are characterized by behavioral pattern such as avoidance, hyperarousal and intrusive thoughts. Occurrence of these symptoms was recorded to calculate score for PTSD symptom. Higher score indicate higher severity.

The score found reduced by 30% in patients who are on Angiotensin II Receptor Blockers or ACE inhibitors. To be specific, ACE inhibitors and ARB drugs lowered intrusive thoughts and hyperarousal. No change in score was reported for those who were taking other types of antihypertensive drugs.

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